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將帶有線條的自定義元素添加到 ggplot object?

[英]Add a custom element with lines to a ggplot object?

我使用ggplot2制作了 Kaplan Meier plot,它表示 3 組患者之間的無病生存率(以 % 為單位):未暴露於風險因素( No exposure )、暴露於風險因素 1( Exposure 1 )或那些暴露於風險因素 2( Exposure 2 )。 數據和 plot 如下所示:

# Load packages
library(tidyverse)
library(magrittr)

# Get data.
data <- 
structure(list(time = c(15.4661190965092, 14.2340862422998, 14.8501026694045, 
9.94934976043806, 4.5119780971937, 7.76454483230664, 12.3121149897331, 
11.7344284736482, 15.6030116358658, 11.9123887748118, 13.9493497604381, 
3.09377138945927, 9.97672826830938, 6.24229979466119, 11.0362765229295, 
12.3805612594114, 9.28405201916495, 3.75633127994524, 6.88021902806297, 
14.2614647501711, 1.95208761122519, 13.3744010951403, 10.4804928131417, 
12.1149897330595, 11.668720054757, 11.211498973306, 5.50855578370979, 
7.61396303901437, 0.939082819986311, 7.0362765229295, 12.911704312115, 
16.0574948665298, 5.34702258726899, 13.3032169746749, 5.637234770705, 
15.0800821355236, 14.1601642710472, 12.7638603696099, 15.6796714579055, 
6.07802874743327, 15.2142368240931, 11.8001368925394, 2.92676249144422, 
10.5051334702259, 10.072553045859, 15.9479808350445, 4.84052019164956, 
4.36960985626283, 12.7775496235455, 15.0280629705681, 13.8891170431211, 
2.2258726899384, 8.90622861054073, 14.7433264887064, 4.61875427789186, 
2.81998631074606, 11.0225872689938, 7.67145790554415, 13.9958932238193, 
9.27310061601643, 15.4496919917864, 11.8986995208761, 11.9972621492129, 
13.7604380561259, 2.8993839835729, 5.82614647501711, 8.0684462696783, 
13.4455852156057, 3.06091718001369, 10.9869952087611, 13.1471594798083, 
14.1273100616016, 13.7577002053388, 6.88021902806297, 11.7973990417522, 
10.3819301848049, 5.47843942505133, 14.2477754962355, 6.94045174537988, 
9.94387405886379, 4.54483230663929, 8.18891170431212, 13.7960301163587, 
8.27104722792608, 14.2422997946612, 14.5325119780972, 14.3655030800821, 
14.072553045859, 3.64681724845996, 6.3791923340178, 10.5434633812457, 
11.378507871321, 14.9322381930185, 14.0123203285421, 2.48323066392882, 
14.8583162217659, 9.88364134154689, 12.145106091718, 15.5838466803559, 
2.80082135523614, 12.9007529089665, 3.50718685831622, 13.3771389459274, 
10.5379876796715, 15.2525667351129, 16.2299794661191, 16.1779603011636, 
8.2217659137577, 15.315537303217, 11.7289527720739, 10.9568788501027, 
13.2676249144422, 7.32375085557837, 11.6112251882272, 5.66735112936345, 
15.7782340862423, 10.113620807666, 9.5523613963039, 1.83983572895277, 
13.5003422313484, 9.6208076659822, 13.9575633127995, 10.9377138945927, 
3.63860369609856, 10.4284736481862, 10.9678302532512, 13.4209445585216, 
15.233401779603, 4.70088980150582, 12.4024640657084, 14.6830937713895, 
13.2977412731006, 0.717316906228611, 12.9691991786448, 7.9315537303217, 
15.6386036960986, 5.82340862422998, 1.0321697467488, 9.89459274469541, 
15.0280629705681, 13.4483230663929, 10.6639288158795, 3.39493497604381, 
12.3203285420945, 4.47364818617385, 14.839151266256, 14.2669404517454, 
6.12183436002738, 13.2101300479124, 3.39493497604381, 15.9671457905544, 
15.9479808350445, 11.9753593429158, 5.46475017111567, 15.9425051334702, 
7.35934291581109, 5.87268993839836, 9.12525667351129, 15.2717316906229, 
6.80082135523614, 14.8583162217659, 12.974674880219, 14.6967830253251, 
13.5797399041752, 11.1321013004791, 3.87679671457906, 14.8336755646817, 
12.5585215605749, 15.6988364134155, 7.60574948665298, 3.40041067761807, 
15.9288158795346, 14.9733059548255, 15.066392881588, 10.2067077344285, 
13.223819301848, 5.34976043805613, 12.0766598220397, 10.9787816563997, 
11.9123887748118, 11.0581793292266, 14.5763175906913, 14.0533880903491, 
4.95003422313484, 4.75290896646133, 14.009582477755, 11.2087611225188, 
14.6776180698152, 15.4086242299795, 10.4421629021218, 6.7378507871321, 
13.9466119096509, 4.22724161533196, 13.7960301163587, 15.7399041752225, 
10.92128678987, 10.425735797399, 11.772758384668, 7.86036960985626, 
2.16837782340862), surv = c(78.895930965634, 82.939817991606, 
81.5385905661846, 90.8500347161838, 96.6504495720828, 91.58932785697, 
84.5274669486008, 87.864369728858, 78.895930965634, 84.8697422025156, 
85.3203796168142, 98.3662199572867, 90.7869444142976, 94.5490389303011, 
89.2078379065114, 84.5274669486008, 90.2944085152522, 98.1562293390666, 
93.3334692912905, 82.939817991606, 98.985749325359, 82.1548721677423, 
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95.7331254544023, 93.6935385308075, 99.6460813737672, 94.5056490644159, 
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95.3815962299675, 80.6002593845599, 84.7887574138549, 83.4729026727989, 
80.6002593845599, 95.9831917973004, 80.6002593845599, 89.7929243747343, 
99.0875137586307, 90.2111674121547, 90.7238102387661, 76.5051451787966, 
96.3102631366802, 97.7311888493258, 86.0777214686932, 78.895930965634, 
83.8785010948376, 98.314751291989, 92.5659794066876, 83.781286869923, 
98.2869267301137, 97.7713225402138, 89.2078379065114, 93.6351988430548, 
81.2409555449192, 93.1602670358451, 80.6002593845599, 87.4920568725144, 
87.3419845128403, 81.9494849873229, 99.0875137586307, 95.2639863702512, 
91.0806705136385, 82.1548721677423, 97.661713434227, 89.2078379065114, 
85.655814846093, 83.3214762866605, 84.4919464607611, 94.7936368159517, 
87.7902851000815, 90.2763488914987, 96.7044696855362, 82.939817991606, 
93.3334692912905, 92.5628179141593, 97.5706519561467, 93.1645493591, 
86.0531379063549, 93.1645493591, 84.1840815183361, 82.3344918532314, 
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90.1453198447006, 85.9984807940096, 83.781286869923, 81.2409555449192, 
98.6774838813241, 81.5385905661846, 90.8500347161838, 88.9048039353159, 
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83.781286869923, 93.1645493591, 80.6002593845599, 89.7929243747343, 
89.2760917993244, 85.2219677930458, 94.1584114615132, 85.2009723473868, 
95.3815962299675, 80.6002593845599, 88.6666313027254, 92.7135716892638, 
99.0367729074855, 82.1548721677423, 91.1603170857887, 81.2409555449192, 
86.9365304945406, 98.1562293390666, 87.9644206553892, 89.2760917993244, 
86.2760734967859, 78.895930965634, 96.3102631366802, 88.346042509788, 
81.9649615708496, 85.1341100942901, 99.7978010383687, 85.9104175149211, 
91.3354416199704, 83.781286869923, 97.331847814204, 99.2663520529959, 
90.8500347161838, 83.781286869923, 82.1548721677423, 87.381862836735, 
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80.9518418241188, 94.6690250203142, 87.5562613738938, 97.661713434227, 
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90.9662877861838, 87.4920568725144, 89.1387381095273, 83.781286869923, 
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88.7910269824191, 82.161520231691, 78.895930965634, 87.9644206553892, 
94.9657807279154, 83.7720562964939, 97.837707856246, 84.3912409226673, 
83.781286869923, 91.129896217454, 90.2763488914987, 85.0368086241741, 
93.4005596740821, 98.314751291989), lower = c(0.755667688497813, 
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0.897551578919665, 0.820019853431481, 0.863148812330468, 0.755667688497813, 
0.823769915532008, 0.82529154050371, 0.978063457368602, 0.894482670798819, 
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0.975612430794298, 0.917004792829363, 0.810065890746191, 0.985444832247924, 
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"Exposure 3", "Exposure 1", "Exposure 3", "Exposure 1", "Exposure 1", 
"Exposure 3", "Exposure 1", "Exposure 3", "Exposure 1", "Exposure 3", 
"Exposure 3", "Exposure 1", "Exposure 1", "Exposure 1", "Exposure 3", 
"Exposure 1", "Exposure 3", "Exposure 2", "Exposure 3", "Exposure 1", 
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"Exposure 3", "Exposure 1", "Exposure 1", "Exposure 3", "Exposure 1", 
"Exposure 3", "Exposure 1", "Exposure 2", "Exposure 2", "Exposure 3", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 2", "Exposure 3", 
"Exposure 3", "Exposure 3", "Exposure 3", "Exposure 1", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 1", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 2", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 3", "Exposure 2", "Exposure 1", "Exposure 1", "Exposure 1", 
"Exposure 3", "Exposure 2", "Exposure 3", "Exposure 1", "Exposure 1", 
"Exposure 1", "Exposure 2", "Exposure 2", "Exposure 2", "Exposure 2", 
"Exposure 1", "Exposure 3", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 2", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 3", "Exposure 1", 
"Exposure 3", "Exposure 2", "Exposure 1", "Exposure 3", "Exposure 1", 
"Exposure 3", "Exposure 3", "Exposure 1", "Exposure 3", "Exposure 1", 
"Exposure 2", "Exposure 3", "Exposure 3", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 3", "Exposure 2", 
"Exposure 2", "Exposure 3", "Exposure 1", "Exposure 2", "Exposure 3", 
"Exposure 3", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 2", 
"Exposure 3", "Exposure 3", "Exposure 2", "Exposure 3", "Exposure 3", 
"Exposure 2", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 3", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 1", "Exposure 3", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 3", "Exposure 2", "Exposure 1", "Exposure 3", "Exposure 1", 
"Exposure 2", "Exposure 3", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 2", "Exposure 1", "Exposure 1", 
"Exposure 2", "Exposure 2", "Exposure 3", "Exposure 3", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 3", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 2", 
"Exposure 1", "Exposure 3", "Exposure 1", "Exposure 3")), class = "data.frame", row.names = c(NA, 
-200L))

# Make the plot:
data %>% 
  ggplot(aes(x=time, y=surv)) + 
  geom_line(aes(color=group), size=0.3) + 
  scale_y_continuous(name="Disease-free survival (%)") +
  scale_x_continuous(name="Follow-up time (years)") +
  scale_color_manual(name="Groups", 
                     values=c("Exposure 1"="firebrick3", "Exposure 2"="#255B1D", "Exposure 3"="darkblue"), 
                     labels=c("Exposure 1 (p<.01)", "Exposure 2 (p=.02)", "Exposure 3 (p=.03)")) + 
  theme_classic() + 
  theme(legend.position=c(0.3, 0.3))

這會產生以下 plot: 在此處輸入圖像描述

在此圖中,p 值表示每組與未暴露組之間的生存差異(使用對數秩檢驗)。 現在我還比較了兩個暴露組Exposure 1Exposure 2之間的存活率,其 p 值為 p=.01。 我想通過以下方式將其添加到 plot: 在此處輸入圖像描述

我已經在 Paint 中做了這個(非常丑陋的)改編,但我希望能夠在 R 中完成這個。有幫助嗎?

也許最簡單的方法是繪制您自己的圖例,這樣您就無需猜測將線條放在哪里,並且在 plot 調整大小時相對位置保持不變:

data %>% 
  ggplot(aes(x=time, y=surv)) + 
  geom_line(aes(color=group), size=0.3) + 
  scale_y_continuous(name = "Disease-free survival (%)") +
  scale_x_continuous(name = "Follow-up time (years)") +
  scale_color_manual(name = "Groups", 
                     values=c("firebrick3", "#255B1D", "darkblue")) +
  geom_line(data = data.frame(time = c(3.9, 5, 3.9, 5, 3.9, 5),
                              surv = c(84, 84, 83, 83, 82, 82),
                              group = rep(paste('Exposure', 1:3), each = 2)),
            aes(color = group)) +
  geom_text(data = data.frame(time = c(5.3, 5.3, 5.3, 10), 
                              surv = c(84, 83, 82, 82.5),
                              group = c("No Exposure", "Exposure 1 (p = 0.02)",
                                        "Exposure 2 (p = 0.03)", "p = 0.01")),
            aes(label = group), hjust = 0, size = 3.2) +
  geom_path(data = data.frame(time = c(9, 9.5, 9.5, 9), 
                              surv = c(82, 82, 83, 83))) +
  annotate('text', x = 3.8, y = 85.2, label = "Groups", hjust = 0, size = 4) +
  theme_classic() + 
  theme(legend.position = 'none')

在此處輸入圖像描述

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