Shifting Cells values in Python

Question

I have the following DataFrame:

SampleTable

Hence the header of the table I imported is divided in two cells I need to shift the cells of the first two columns to shift up. And then to shift the 3 and 4 up. For it to look like this:

What I need

I have tried

df.at[1,'x'] = None

But that just deletes de value without shifting any cell.

What I get

Answer 1

Get the header with

df.columns = df.loc[0].iloc[:2].tolist() + df.columns[2:].tolist()
df = df.loc[1:].reset_index(drop=True)

   A  B  C  D
0  1  2  3  4