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How subtract group columns values in python pandas?

products.groupby(["Product Category"])[["Product Cost","Selling Cost"]].sum()

How to find Selling Margin?

You can use assign to refer to a column in a chain

(products
.groupby(["Product Category"])[["Product Cost","Selling Cost"]]
.sum()
.assign(margin = lambda x: x['Selling Cost'] - x['Product Cost']))

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