win32api vs Python

Question

What are the Pro's and Con's of using win32api for I/O and other things instead of simply Python, if both have a specific function for it

I mean, using PyWin32 vs Win32Api

Answer 1

con

• (lack of) portability
• harder/more error prone

pro

• performance (potentially, it must be measured, as will depend on more than just the api calls)

Answer 2

The most obvious thing seems to be losing cross-platform compatibilty. Python runs on a number of different platforms, none of which has a win32 API except MS Windows.