You're currently targeting any device and not just hololens. Since you want to make an application for the HoloLens I'm guessing you already have the Holotoolkit imported.
If you haven't, then I'd recommend you do so as this is a great starting point for any Hololens application and it has a lot of useful tools which will make developing for hololens much easier.
If you do, you can select the Holotoolkit -> configure -> project settings. This will configure your project settings for the Hololens. When you've done that you should be able to use Debugging C# projects
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