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can I change the Window system format via python?

I have a program that is using . as decimal symbol. But my friend in Vietnam uses , as decimal symbol. Is there a way to change that using a python script?
Edit 1: I'm talking about system wide. I need a python script that autochange system decimalsymbol to the dot '.'. Thank @CristiFati

I'm done with Googling. Just using registry and set decimal value.

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