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Dajaxice performance measures for high-traffic site

If this question has already been answered by someone on this site, please point me there.

Is it a good option to use Dajaxice for a high-traffic website, assuming millions of hits per day? Has anybody faced performance issues in terms of load-times for web pages with multiple AJAX calls to server?

What are the alternatives for Python+Django projects? Is it better to use just jQuery?

In my experience the main load in the web application laying on databases. Not on frameworks or templates engines.

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