In matlab, it is possible to execute a script (ie an m-file) and then manipulate the variables created by the script on the command line.
Is it possible to run a.py file on PyDev and consequently, manipulate its variables inside eclipse as is possible in the case of matlab?
That's available through the PyDev interactive console. See: http://pydev.org/manual_adv_interactive_console.html
Another way would be executing some program in debug mode and inspecting variables in the console: http://pydev.org/manual_adv_debug_console.html
Yes, check the run configurations. You can add the script as a "Python Run".
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