I work with python 2.7.8 and i use this code to close all open applications:
import os,subprocess
os.system('taskkill /im chrome.exe')
os.system('taskkill /im POWERPNT.exe')
os.system('taskkill /im OUTLOOK.exe')
os.system('taskkill /im WINWORD.exe')
os.system('taskkill /im ArcMap.exe')
os.system('taskkill /im acadlt.exe')
os.system('taskkill /im EXCEL.exe')
os.system('taskkill /im AcroBat.exe')
os.system('taskkill /im wmplayer.exe')
subprocess.call('nircmd.exe win close class "CabinetWClass"' , shell=True)
I succeed to close all applications except OUTLOOK and all the open folder of the windows 7 Professional
Try restart explorer.exe to close open folders.
os.system('taskkill /im explorer.exe')
os.system('explorer.exe')
Try f (force) parameter to force Outlook to close.
os.system('taskkill /f /im OUTLOOK.exe')
Also you can try this; https://stackoverflow.com/a/4230226/4471283
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