samtools - dyld: Library not loaded: @rpath/libcrypto.1.0.0.dylib

Question

I have seen a few other questions like this elsewhere but I can't seem to find a resolution that works for me. I am trying to run samtools using python on anaconda. I am running macosx catalina. Here is the error code

dyld: Library not loaded: @rpath/libcrypto.1.0.0.dylib
  Referenced from: /Users/me/anaconda3/bin/samtools
  Reason: image not found
zsh: abort      samtools

I have tried all sorts of efforts to install an earlier version of openssl through anaconda but it still shows that I have openssl version 1.1.1 installed.

Thanks for any guidance on how to either (a) install an earlier version of openssl through anaconda or (b) direct samtools to evaluate a different path for an earlier version or (c) any other solution.

Answer 1

Ok, so I am open to other solutions but this is what worked for me if anyone else runs into this issue.

I downloaded the package from sourceforge ( https://sourceforge.net/projects/samtools/ ) and compiled it as the readme file states. Instead of running samtools from the anaconda package that is in my path I moved this newly compiled file to the folder of interest. I call it from there as follows:

cd users/me/desktop/example  (where samtools executable lives in this folder)

./samtools etc etc

I know this is basic for many but not for me and I hope it is helpful to anyone else who has this issue in the future